Preliminary scientific program

21 July 2014
14:00		Registration starts
16:00		Opening ceremony Opening keynote lecture: Douglas Lauffenburger, MIT, USA Dynamical Feedback Circuits in Cell Biology: Network Analysis of Proteolytic Shedding Effects on Receptor/Ligand Signaling
17:30		Welcome reception and dinner
20:30		Informal evening program (bowling, table soccer, swimming, etc)

22 July 2014 Structural biology and high-throughput experimental techniques
9:00		*Keynote lecture:* Giulio Superti-Furga, CeMM, Austria Genes, protein, protein complexes and environmental exchange: Understanding drug action in the context of environmental complexity
9:45		*Expert talk:* Rune Linding, Technical University of Denmark, Denmark Decoding network dynamics in cancer
10:15		*Expert talk:* Anne-Claude Gavin, EMBL, Germany Lipid transport in budding yeast
10:45		Tea/coffee break
11:15		*Expert talk:* Gabor Balogh, BRC, Hungary Lipidomics: Role of lipids in signalling networks
11:45		*Contributed talks:*
		Laszlo Buday, MTA-TTK, Hungary Tks scaffold proteins in tyrosine kinase signalling
		Ivana Vonkova, EMBL, Germany A systematic analysis of the PH domain recruitment to membranes using novel liposome microarray-based assay
		Christin Zasada and Raphaela Fritsche, Max-Delbrueck-Center Berlin, Germany From signaling to metabolism and vice versa
12:30		Lunch
		Teamwork – part 1
14:00		Getting know each other
14:30		Presenting the problem to be solved
16:45		Tea/coffee break
17:15		Medieval team building competition, informal discussions in the meantime
19:00		Dinner
21:30		Poster session 1
22:30		Informal evening program

23 July 2014 Network modelling
9:00		*Keynote lecture:* Boris Kholodenko, University College Dublin, Ireland Catching signals surfing the net
9:45		*Expert talk:* Laurence Calzone, INSERM at Institut Curie, France Mathematical modelling of bladder tumorigenesis to explain co-occurrence and exclusivity of genetic alterations
10:15		*Expert talk:* Julio Saez-Rodriguez, EMBL-EBI, United Kingdom Logic modelling of signalling networks in disease
10:45		Tea/coffee break
11:15		*Contributed talks:*
		Attila Csikasz-Nagy, Kings College London, United Kingdom Epithelial topology dynamics in tissue homeostasis and tumorigenesis
		Abulikemu Abudukelimu, VU University Amsterdam, The Netherlands One stone, two birds: a therapy to both inflammation and tumorigenesis in a complex model of tumor incited inflammation
		Aaron Meyer, MIT, USA The AXL Receptor is a Sensor of Ligand Spatial Heterogeneity
		Orsolya Kapuy, Semmelweis University, Hungary A systems-level study of mTOR-regulated autophagy induction during endoplasmic reticulum stress
		Alexey Kolodkin, Luxembourg Centre for Systems Biomedicine, Luxemburg ROS-activated signaling network: dynamic modelling and design principles study
12:30		Lunch
		Teamwork – part 2
14:00		Discussing the problem to be solved
15:30		Catamaran boat trip in the Danube Bend (each team in each catamaran)
17:00		Tea/coffee break
17:30		Summary activity on the problem, creating a presentation
19:00		Dinner
21:30		Poster session 2
22:30		Informal evening program

24 July 2014 Signaling systems & network medicine
9:00		*Keynote lecture:* Hans Westerhoff, BioCentrum Amsterdam, The Netherlands Signalling principles
9:45		*Expert talk:* Peter Csermely, Semmelweis University, Hungary Adaptation of molecular networks and their use in drug design: a signaling perspective
10:15		*Expert talk:* Paul Bates, Cancer Research, United Kingdom Modelling Tumour Heterogeneity and Metastasis
10:45		Tea/coffee break
11:15		*Contributed talks:*
		Sakshi Gulati, Cancer Research, UK – LRI, United Kingdom Comprehensive analysis of molecular markers associated with survival and the impact of intratumour heterogeneity in clear cell renal cell carcinoma
		Ferenc Gallyas, University of Pecs, Hungary Mitochondrial network dynamics, tumour malignancy and small heat-shock protein expression: Is there a connection?
		Alba Gutiérrez, Universitat Pompeu Fabra, Hospital del Mar Medical Research Institute, Spain A network medicine approach to explore comorbiditiy patterns in Catalonia
		Nadezhda Doncheva, Max Planck Institute for Informatics, Germany Dynamic residue interaction networks for understanding signaling protein interactions
		András Zeke, MTA-TTK, Hungary Identifying novel mitogen-activated protein kinase partners by a combined structural, sequence-based & evolutionary analysis
12:30		Lunch
14:00		*Contributed talks* Further signaling network topics
		Katalin Toth, University of Missouri, USA Phosphorylation events involved in early perception of soybean rhizobial symbiont B. Japonicum
		Bhaswar Ghosh, ZMBH, University of Heidelberg, Germany Evolutionary Flexibility achieved through phosphatase sharing in multilayer MAPK cascade
		Nilgun Yilmaz, VU University Amsterdam, The Netherlands Low stress weekends promote adaptation to stressful weeks, or do they?
14:45		Maria Victoria Schneider, TGAC, United Kingdom How to be an interdisciplinary scientist – integrated discussion on the needs and requests
15:30		Presentation of teams (10 minutes/team)
16:45		Tea/coffee break
17:15		Discussing group presentations, novel ideas, and concrete actions (e.g. collaborations)
18:00		Closing Keynote: Toby Gibson, EMBL, Germany Regulation by Molecular Switching
19:00		Renaissance Farewell Feast, Award presention for teams and poster presenters Closing remarks
22:00		Informal evening program with music

25 July 2014 Departure’s day