Preliminary scientific program

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21 July 2014

14:00   Registration starts
16:00   Opening ceremony
Opening keynote lecture:

Douglas Lauffenburger, MIT, USA
Dynamical Feedback Circuits in Cell Biology: Network Analysis of Proteolytic Shedding Effects on Receptor/Ligand Signaling

17:30   Welcome reception and dinner
20:30   Informal evening program
(bowling, table soccer, swimming, etc)

22 July 2014

Structural biology and high-throughput experimental techniques

9:00   Keynote lecture:

Giulio Superti-Furga, CeMM, Austria
Genes, protein, protein complexes and environmental exchange: Understanding drug action in the context of environmental complexity

9:45   Expert talk:

Rune Linding, Technical University of Denmark, Denmark
Decoding network dynamics in cancer

10:15   Expert talk:

Anne-Claude Gavin, EMBL, Germany
Lipid transport in budding yeast

10:45   Tea/coffee break
11:15   Expert talk:

Gabor Balogh, BRC, Hungary
Lipidomics: Role of lipids in signalling networks

11:45   Contributed talks:

Laszlo Buday, MTA-TTK, Hungary
Tks scaffold proteins in tyrosine kinase signalling


Ivana Vonkova, EMBL, Germany
A systematic analysis of the PH domain recruitment to membranes using novel liposome microarray-based assay


Christin Zasada and Raphaela Fritsche, Max-Delbrueck-Center Berlin, Germany
From signaling to metabolism and vice versa

12:30   Lunch
    Teamwork – part 1
14:00   Getting know each other 
14:30   Presenting the problem to be solved
16:45   Tea/coffee break
17:15   Medieval team building competition, informal discussions in the meantime
19:00   Dinner
21:30   Poster session 1
22:30   Informal evening program

23 July 2014

Network modelling

9:00   Keynote lecture:

Boris Kholodenko, University College Dublin, Ireland
Catching signals surfing the net

9:45   Expert talk:

Laurence Calzone, INSERM at Institut Curie, France
Mathematical modelling of bladder tumorigenesis to explain co-occurrence and exclusivity of genetic alterations

10:15   Expert talk:

Julio Saez-Rodriguez, EMBL-EBI, United Kingdom
Logic modelling of signalling networks in disease

10:45   Tea/coffee break
11:15   Contributed talks:

Attila Csikasz-Nagy, Kings College London, United Kingdom
Epithelial topology dynamics in tissue homeostasis and tumorigenesis


Abulikemu Abudukelimu, VU University Amsterdam, The Netherlands
One stone, two birds: a therapy to both inflammation and tumorigenesis in a complex model of tumor incited inflammation


Aaron Meyer, MIT, USA
The AXL Receptor is a Sensor of Ligand Spatial Heterogeneity


Orsolya Kapuy, Semmelweis University, Hungary
A systems-level study of mTOR-regulated autophagy induction during endoplasmic reticulum stress


Alexey Kolodkin, Luxembourg Centre for Systems Biomedicine, Luxemburg
ROS-activated signaling network: dynamic modelling and design principles study

12:30   Lunch
    Teamwork – part 2
14:00   Discussing the problem to be solved
15:30   Catamaran boat trip in the Danube Bend (each team in each catamaran)
17:00   Tea/coffee break
17:30   Summary activity on the problem, creating a presentation
19:00   Dinner
21:30   Poster session 2
22:30   Informal evening program

24 July 2014

Signaling systems & network medicine

9:00   Keynote lecture:

Hans Westerhoff, BioCentrum Amsterdam, The Netherlands
Signalling principles

9:45   Expert talk:

Peter Csermely, Semmelweis University, Hungary
Adaptation of molecular networks and their use in drug design: a signaling perspective

10:15   Expert talk:

Paul Bates, Cancer Research, United Kingdom
Modelling Tumour Heterogeneity and Metastasis

10:45   Tea/coffee break
11:15   Contributed talks:

Sakshi Gulati, Cancer Research, UK – LRI, United Kingdom
Comprehensive analysis of molecular markers associated with survival and the impact of intratumour heterogeneity in clear cell renal cell carcinoma


Ferenc Gallyas, University of Pecs, Hungary
Mitochondrial network dynamics, tumour malignancy and small heat-shock protein expression: Is there a connection?


Alba Gutiérrez, Universitat Pompeu Fabra, Hospital del Mar Medical Research Institute, Spain
A network medicine approach to explore comorbiditiy patterns in Catalonia


Nadezhda Doncheva, Max Planck Institute for Informatics, Germany
Dynamic residue interaction networks for understanding signaling protein interactions


András Zeke, MTA-TTK, Hungary
Identifying novel mitogen-activated protein kinase partners by a combined structural, sequence-based & evolutionary analysis

12:30   Lunch
14:00   Contributed talks
Further signaling network topics

Katalin Toth, University of Missouri, USA
Phosphorylation events involved in early perception of soybean rhizobial symbiont B. Japonicum


Bhaswar Ghosh, ZMBH, University of Heidelberg, Germany
Evolutionary Flexibility achieved through phosphatase sharing in multilayer MAPK cascade


Nilgun Yilmaz, VU University Amsterdam, The Netherlands
Low stress weekends promote adaptation to stressful weeks, or do they?


Maria Victoria Schneider, TGAC, United Kingdom
How to be an interdisciplinary scientist – integrated discussion on the needs and requests

15:30   Presentation of teams
(10 minutes/team)
16:45   Tea/coffee break
17:15   Discussing group presentations, novel ideas, and concrete actions (e.g. collaborations)
18:00   Closing Keynote:

Toby Gibson, EMBL, Germany
Regulation by Molecular Switching

19:00   Renaissance Farewell Feast,
Award presention for teams and poster presenters
Closing remarks
22:00   Informal evening program with music

25 July 2014

Departure’s day


Late registration deadline
15 June 2014